Comparison between laparoscopic and open surgical high ligation of the internal spermatic vein / 中华男科学杂志

<p><b>OBJECTIVE</b>To compare the effects of laparoscope-guided high ligation of the internal spermatic vein and open surgery in the treatment of varicocele.</p><p><b>METHODS</b>We collected the clinical data of 85 cases of varicocele treated by laparoscope-guided high ligation of the internal spermatic vein (the laparoscopic group) and another 47 that underwent open surgery (the open group) , and compared the results of treatment between the 2 groups.</p><p><b>RESULTS</b>The operations were successful in all the cases. In the laparoscopic group, the mean operation time was (32.0 +/- 5.9) minutes, with little bleeding, and the mean postoperative hospital stay was (3.0 +/- 1.6) days, with 3 cases (3.5%) of recurrence during the 3-12 months follow-up. In the open group, the mean operation time was (46.0 +/-7.2) minutes and the mean postoperative hospital stay was (7.0 +/- 3.7) days, with 5 cases (10.6%) of recurrence during the same length of follow-up.</p><p><b>CONCLUSION</b>Laparoscopic method for the treatment of varicocele is obviously superior to open surgery for its advantages of minimal invasiveness, fast recovery, sure effectiveness, few complications and low recurrence, particularly for those with bilateral varicocele who experienced recurrence after open surgery.</p>

Shengjing Granule for varicocele in rats / 中华男科学杂志

<p><b>OBJECTIVE</b>To study the influence and therapeutic effect of the Chinese herbal drug Shengjing Granule on varicocele in rats.</p><p><b>METHODS</b>A total of 80 male Sprague-Dawley rats were equally randomized into a sham operation group and 3 varicocele model groups, and the latter 3 again subdivided into a model, a Shengjing and a Clomifene group. Fifteen days after the modeling, the Shengjing and the Clomifene groups were intragastrically given Shengling Granule and Clomifene at the dose of 4 g/(kg x d) and 20 mg/(kg x d), respectively, while the model and sham operation groups were on normal diet. Thirty days later, the effects of Shengjing Granule were assessed by determining such serum sexual hormones as FSH, LH and T and observing the morphological changes of the testes of different groups of rats under the light microscope.</p><p><b>RESULTS</b>The testis constitution was better and the levels of FSH and LH were significantly lower in the Shengjing group than in the model and Clomifene groups (P<0.05) but markedly higher in the Clomifene group than in the other three. The T level showed no obvious difference among the Shengjing, Clomifene and sham operation groups but was significantly higher in the three groups than in the model group (P<0.05).</p><p><b>CONCLUSION</b>Shengjing Granule can not only protect the testis from but also repair varicocele-induced injury, probably with a better efficacy than Clomifene.</p>

Shengjing granule: an effective Chinese medicine for spermatogenic disturbance in mice / 中华男科学杂志

<p><b>OBJECTIVE</b>To observe the effect of the Chinese medicine Shengjing Granule on spermatogenic disturbance in mice.</p><p><b>METHODS</b>Forty-six male Kunming mice were randomly divided into a normal (n = 10), a model (n = 12), a control (n = 12) and a Shengjing group (n = 12), and models of spermatogenic disturbance were established by intraperitoneal injection of cyclophosphamide in the latter three. Then the first two groups received intragastric administration of physiological saline and the second two that of clomiphene (21.6 mg/kg x d) and Shengjing Granule (16 g/kg x d), respectively, all for 15 days. On the following day, the testis weight was measured, the levels of the follicle stimulating hormone (FSH), the luteinizing hormone (LH) and testosterone (T) determined by radioimmunoassay. Histological observations were made of the testis tissues under the microscope.</p><p><b>RESULTS</b>The testis index and T level were (3.958 +/- 0.342) g/kg and (7.046 +/- 0.291) nmo/L, obviously increased, while the levels of FSH and LH were (2.947 +/- 0.587) mIU/ml and (3.254 +/- 0.492) mIU/ml, significantly decreased, in the Shengjing group, as compared with (3.525 +/- 0.462) g/kg, (6.231 +/- 0.317) nmol/L, (5.428 +/- 0.719) mIU/ml and (5.155 +/- 0.460) mIU/ml in the model group (P < 0.05). The number of spermatogenic cells on the seminiferous tubules and that of sperm in the lumina of the tubules were markedly increased in the Shenginjg group, compared with the models. CoCONCLUSIONShenginjg Granule is effective for spermatogenic disturbance in mice.</p>